在我国,很多慢病患者存在多病共存的情况,往往会用到多种药物。
然而,多种药物间可能存在相互作用,即通过生化反应产生相互影响,使一种或多种药物的吸收、分布、排泄、代谢和药理作用发生改变,从而产生相加作用、增强作用、增敏作用和拮抗作用。
为了防止不良反应的发生,合理的用药搭配,也是每一位医生/药师的用药基本功。针对药物相互作用的问题,下面将通过“界表格”的形式,与医生/药师朋友一同助力合理用药,供临床用药参考。
通过这个1个案例和5张表格,我们来一起分析:
参考来源:
[1]Sohn S,Kwon K.Accelerated Thrombotic Occlusion of a Medium-Sized Coronary Aneurysm in Kawasaki Disease by the Inhibitory Effect of Ibuprofen on Aspirin[J].Pediatric Cardiology,2008,29(1):153-156.
[2]Catella-Lawson F,Reilly MP,Kapoor SC et al:Cyclooxygenase inhibitors and the antiplatelet effects of aspirin.New Engl J Med 2001;345(25):1809-1817.
[3]Hohlfeld T:High on treatment platelet reactivity against aspirin by non-steroidal anti-inflammatory drugs--pharmacological mechanisms and clinical relevance.Thromb Haemost May,2013;109(5):825-833.
[4]MacDonald TM&Wei L:Effect of ibuprofen on cardioprotective effect of aspirin.Lancet 2003;361(9357):573-574.
[5]Product Information:DUEXIS(R)oral tablets,ibuprofen famotidine oral tablets.Horizon Pharma USA,Inc.(per FDA),Lake Forest,IL,Jul,2019.
[6]Product Information:DURLAZA(TM)oral extended release capsules,aspirin oral extended release capsules.New Haven Pharmaceuticals(per manufacturer),North Haven,CT,Sep,2015.
[7]US Food and Drug Administration:New Information for Healthcare Professionals Concomitant Use of Ibuprofen and Aspirin.US Food and Drug Administration,Rockville,MD,Sep 8,2006.
[8]https://www.micromedexsolutions.com/micromedex2/librarian/PFDefaultActionId/evidencexpert.ShowDrugInteractionsResults
[9]Product Information:digoxin oral solution,digoxin oral solution.Roxane Laboratories,Inc.(per FDA),Columbus,OH,Nov,2011.
[10]https://www.micromedexsolutions.com/micromedex2/librarian/PFDefaultActionId/evidencexpert.ShowDrugInteractionsResults
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